Senior Scientist / Associate Principal Scientist- Medicinal Chemistry & Targeted Delivery
AstraZeneca

Job Info

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At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As a part of our Protein Engineering team in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.

About AstraZeneca in Gaithersburg, MD

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the Group

The Antibody Discovery and Protein Engineering (ADPE) department at AstraZeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're utilizing our expertise in protein and antibody engineering to enable novel therapeutic approaches to Oncology, Respiratory, Inflammatory, Cardiovascular and Infectious disease. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore new and exciting technologies.

Main Duties and Responsibilities:

In this role, you will be part of a team of highly skilled and passionate individuals responsible for innovating and generating the best in class antibody drug conjugates for various therapeutic areas. We are seeking a highly motivated organic/medicinal chemist with a preferred background in drug discovery. Exciting opportunity to be lead and contribute to multi-disciplinary drug development.

• Design, synthesize and develop multi-step cytotoxic drug-linkers for antibody drug conjugates
• Collaborate and work with a diverse group of scientists across many therapeutic areas, chemistry, and process development to ensure timely progress in research projects and drive technological innovations
• Partner with colleagues on laboratory maintenance, including maintenance of equipment and lab safety.

Education & Experience Requirements:

Graduate Degree in Organic Chemistry or other relevant subject areas with 0-7 years' industrial experience (PhD) or 9+ years' industrial experience (MS)

Required Skills:

• Hands-on expertise in multi-step synthetic organic chemistry, including air-free chemical synthesis and small-scale techniques, purification and characterization of compounds by various tools.
• Knowledgeable in the state-of-the-art synthetic chemistry, structure-based design, ADME, data analysis and analytical and purification methods.
• Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines
• Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset and maintains a detailed laboratory notebook
• Track record of scientific innovation as evidenced by scientific publications, patents, and oral presentations at conferences

Desired Skills:

• Hands-on experience in the synthesis of cytotoxic payloads and linkers for antibody drug conjugates is highly desirable.
• Experience in small parallel library design and synthesis.
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management

Why AstraZeneca
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours.

Where can I find out more
Check out our landing page for more information on our BPD group https://careers.astrazeneca.com/bpd

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