The Reproductive Endocrine Unit (REU) at Massachusetts General Hospital (MGH), a Harvard affiliate, is seeking an enthusiastic and ambitious full-time postdoctoral fellow who demonstrates an interest in reproductive medicine, biology, and genetics.
The mission of our lab focuses on improving the understanding the mechanistic drivers of rare reproductive disorders of human infertility through human genomics, transcriptomics and phenomics. Through increased knowledge about the architecture of infertility, we strive to conduct research that will ultimately lead to meaningful improvements for the care of individuals impacted by the diagnoses we study. To accomplish this work, our lab employs a combination of clinical assessments, physiological studies, large-scale genomic sequencing (DNA, RNA, epigenetic), and functional validation leveraging both patient derived specimens and in vitro/in vivo modeling. Our lab is fortunate to have the opportunity to closely collaborate with physicians and investigators across the globe to create unique clinical cohorts with comprehensive clinical examinations, electronic medical records, biospecimens, and continuing clinical follow-up.
Our laboratory is part of a National Center for Translational Research in Reproduction and Infertility, funded by the National Institute of Child Health and Development (NIH). The Unit is also a new recipient of a Gates Foundation Grand Challenge Award. Dr. Seminara, Unit Chief, is PI on a NIH Merit Award which provides 10 years of funding for her translational studies. Thus, the Unit is securely funded for the next 10 years and is eager to welcome a post-doctoral research fellow for a multi-year professional experience.
Currently, we are interested in recruiting postdoctoral fellow with experience in human induced pluripotent stem cell (hiPSC) derivation and cell model work. We are currently generating hiPSC derived GnRH neurons. We want to investigate the cellular and molecular consequences of genetic variation on GnRH neurons by comparing and contrasting the GnRH transcriptome, morphology, migratory capability and secretory function between wild-type and edited GnRH neurons. This project, along with other work from our Unit and its collaborators, will aid in the diagnosis and management of infertility, inform genetic risk prediction for infertility conditions, and facilitate the development of novel therapeutic options for infertility.
Special Instructions to Applicants:
Subscribe to job alerts and add your resume to our resume database for employers!