Associate Principal Scientist, In-Vivo Model Development
AstraZeneca

Job Info

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Associate Principal Scientist - In Vivo Model Development

Location: Gaithersburg, MD

Why AstraZeneca?

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

This Opportunity

With our innovative pipeline there is a need to develop appropriate mouse models to test our IO molecules. We are seeking an innovative and highly motivated Scientist with a background in immunology or related field to join the Early Discovery Oncology Bioscience team in Gaithersburg, MD. You will lead a team of in vivo scientists and be responsible for creating new mouse models or improving existing mouse models to be used to interrogate the biology of immunomodulatory targets or target pathways using cutting-edge technologies and novel approaches to enrich our immunotherapy pipeline.

Main Activities and Responsibilities

Working in this laboratory-based position within Oncology Research you will develop, design, conduct and analyse both in vivo and in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics with a focus on myeloid targeting.

You will be expected to support cross-functional teams and work collaboratively with project leaders to ensure the timely generation, and dissemination of critical program data, and contribute to scientific publication goals.

As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology, pharmacology and cancer modelling and have a genuine passion for this field of research.

Education Requirement

• PhD (or equivalent experience) in a biological science with 5-10+ years of post-PhD research experience in industry or academia. Industry experience is preferred but exceptional candidates with substantial & relevant academic experience will be considered.

Necessary Skills and Experience Required

• Line management experience (2-4 years)
• General knowledge of biologic drug development.
• The ability to work closely with key leaders in partner functions to ensure that project goals and timelines are adhered to.
• Experience with different in vivo models of cancer including subcutaneous, orthotopic and transgenic/inducible models in both immunocompetent and immunodeficient animals, including sampling and processing of tissues for downstream analysis.
• Experience across multiple model platforms to develop and analyse PD biomarker endpoints in tumors and tissues.
• Designing and implementation of multi-parameter flow cytometry panels (preferred 10+ fluorochromes) and an ability to analyse and plan next steps based on results of experimental outcomes
• Must present with strong interpersonal and collaboration skills, together with evidence of delivery in a team-oriented, collaborative environment.

About Our Gaithersburg Oncology Hub

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

So, what's next?

Are you already envisioning yourself joining our team? Good! We can't wait to hear from you!

If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: December 22, 2022

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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